Genotoxicity and anti-genotoxicity of fennel plant (Foeniculum vulgare Mill) fruit extracts using the somatic mutation and recombination test (SMART)

Anti-mutagenic Effects of Fennel Plant (Foeniculum vulgare Mill) Seeds and Pure Anethole: An in vitro Test on Mice

In the present study Willbutrin (bupropion hydrochloride) was employed to induce mutagenic/ carcinogenic features in mice, i.e. undesirable cell division and DNA damage. The repair actions of fennel dry seeds and its extracted bioactive substance anethole supplied to Willbutrin-treatedmice in a dietary regime were investigated. Male Swiss albino mice (25-30gm) orally received Willbutrin dose (0...

Genotoxicity testing of some metals in the Drosophila wing somatic mutation and recombination test.

High-Throughput In Vivo Genotoxicity Testing: An Automated Readout System for the Somatic Mutation and Recombination Test (SMART)

Genotoxicity testing is an important component of toxicity assessment. As illustrated by the European registration, evaluation, authorization, and restriction of chemicals (REACH) directive, it concerns all the chemicals used in industry. The commonly used in vivo mammalian tests appear to be ill adapted to tackle the large compound sets involved, due to throughput, cost, and ethical issues. Th...

Phytotoxicity and stimulatory impacts of nanosized and bulk titanium dioxide on fennel (Foeniculum vulgare Mill).

The objective of the this study was to compare concentrations of nanosized TiO2 at 0, 5, 20, 40, 60 and 80 mg L(-1) with bulk TiO2 for phytotoxic and stimulatory effects on fennel seed germination and early growth stage. After 14 d of seed incubation, germination percentage highly improved following exposure to 60 ppm nanosized TiO2. Similar positive effects occurred in terms of shoot dry weigh...

Genotoxicity testing of Cecropia obtusifolia extracts in two in vivo assays: the wing somatic mutation and recombination test of Drosophila and the human cytokinesis-block micronucleus test.

Cecropia obtusifolia Bertol. (Cecropiaceae) is a tree that grows in secondary vegetation in the tropical rain forest along both coasts of Mexico. Its leaves are used in folk medicine for the treatment of diabetes mellitus type 2. The aim of the present studies was the evaluation of possible genotoxic effects of the aqueous extract from the leaves of Cecropia obtusifolia by means of two differen...